Project Name Mouse Gut Community 
Domain (1) bacteria
Investigators (1)
Institution Washington University in St. Louis
Project Code CAM_PROJ_MouseGut
Project Type metagenome
Publications (1)


The worldwide obesity epidemic is stimulating efforts to identify host and environmental factors that affect energy balance. Comparisons of the distal gut microbiota of genetically obese mice and their lean littermates, as well as those of obese and lean human volunteers have revealed that obesity is associated with changes in the relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Here we demonstrate through metagenomic and biochemical analyses that these changes affect the metabolic potential of the mouse gut microbiota. Our results indicate that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization of germ-free mice with an .obesemicrobiota. results in a significantly greater increase in total body fat than colonization with a .lean microbiota.. These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity.


Name Code Organism CDS NT Pep
MOUSEGUT_SMPL_MOUSEGUTLEAN1 assembly CAM_ASM_0000507 MOUSEGUT_SMPL_MOUSEGUTLEAN1      
MOUSEGUT_SMPL_MOUSEGUTLEAN2 assembly CAM_ASM_0000508 MOUSEGUT_SMPL_MOUSEGUTLEAN2      
MOUSEGUT_SMPL_MOUSEGUTLEAN3 assembly CAM_ASM_0000509 MOUSEGUT_SMPL_MOUSEGUTLEAN3      
MOUSEGUT_SMPL_MOUSEGUTOB1 assembly CAM_ASM_0000510 MOUSEGUT_SMPL_MOUSEGUTOB1      
MOUSEGUT_SMPL_MOUSEGUTOB2 assembly CAM_ASM_0000511 MOUSEGUT_SMPL_MOUSEGUTOB2      


Sample Name PI Desc Cart
MOUSEGUT_SMPL_MOUSEGUTLEAN1 NA Mouse Gut Community lean1
MOUSEGUT_SMPL_MOUSEGUTLEAN2 NA Mouse Gut Community lean2
MOUSEGUT_SMPL_MOUSEGUTLEAN3 NA Mouse Gut Community lean3
MOUSEGUT_SMPL_MOUSEGUTOB1 NA Mouse Gut Community ob1
MOUSEGUT_SMPL_MOUSEGUTOB2 NA Mouse Gut Community ob2